You are browsing environment: HUMAN GUT
CAZyme Information: MGYG000000111_00133
You are here: Home > Sequence: MGYG000000111_00133
Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Cutibacterium acnes | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Actinobacteriota; Actinomycetia; Propionibacteriales; Propionibacteriaceae; Cutibacterium; Cutibacterium acnes | |||||||||||
| CAZyme ID | MGYG000000111_00133 | |||||||||||
| CAZy Family | GH84 | |||||||||||
| CAZyme Description | O-GlcNAcase NagJ | |||||||||||
| CAZyme Property |
|
|||||||||||
| Genome Property |
|
|||||||||||
| Gene Location | Start: 130771; End: 133686 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH84 | 199 | 508 | 1.8e-100 | 0.9932203389830508 |
| CBM32 | 674 | 798 | 2.2e-21 | 0.9435483870967742 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| pfam07555 | NAGidase | 3.12e-148 | 199 | 507 | 1 | 293 | beta-N-acetylglucosaminidase. This family has previously been described as a hyaluronidase. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity. |
| pfam00754 | F5_F8_type_C | 5.05e-22 | 674 | 797 | 3 | 127 | F5/8 type C domain. This domain is also known as the discoidin (DS) domain family. |
| pfam02838 | Glyco_hydro_20b | 1.69e-21 | 52 | 192 | 2 | 123 | Glycosyl hydrolase family 20, domain 2. This domain has a zincin-like fold. |
| cd00057 | FA58C | 2.37e-10 | 674 | 799 | 15 | 141 | Substituted updates: Jan 31, 2002 |
| smart00231 | FA58C | 2.10e-06 | 674 | 786 | 15 | 127 | Coagulation factor 5/8 C-terminal domain, discoidin domain. Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| ALD69353.1 | 0.0 | 1 | 971 | 1 | 971 |
| AER06669.1 | 0.0 | 30 | 971 | 1 | 942 |
| QTF73146.1 | 0.0 | 13 | 917 | 10 | 920 |
| QGH68398.1 | 1.19e-305 | 7 | 931 | 10 | 926 |
| QJW35068.1 | 2.30e-296 | 52 | 917 | 47 | 912 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6PV5_A | 4.37e-82 | 53 | 560 | 41 | 541 | Structureof CpGH84B [Clostridium perfringens ATCC 13124] |
| 2V5D_A | 8.20e-82 | 51 | 785 | 13 | 716 | Structureof a Family 84 Glycoside Hydrolase and a Family 32 Carbohydrate-Binding Module in Tandem from Clostridium perfringens. [Clostridium perfringens] |
| 2CBI_A | 1.99e-78 | 51 | 564 | 13 | 510 | Structureof the Clostridium perfringens NagJ family 84 glycoside hydrolase, a homologue of human O-GlcNAcase [Clostridium perfringens],2CBI_B Structure of the Clostridium perfringens NagJ family 84 glycoside hydrolase, a homologue of human O-GlcNAcase [Clostridium perfringens],2CBJ_A Structure of the Clostridium perfringens NagJ family 84 glycoside hydrolase, a homologue of human O-GlcNAcase in complex with PUGNAc [Clostridium perfringens],2CBJ_B Structure of the Clostridium perfringens NagJ family 84 glycoside hydrolase, a homologue of human O-GlcNAcase in complex with PUGNAc [Clostridium perfringens],2V5C_A Family 84 glycoside hydrolase from Clostridium perfringens, 2.1 Angstrom structure [Clostridium perfringens],2V5C_B Family 84 glycoside hydrolase from Clostridium perfringens, 2.1 Angstrom structure [Clostridium perfringens],2VUR_A Chemical dissection of the link between Streptozotocin, O-GlcNAc and pancreatic cell death [Clostridium perfringens],2VUR_B Chemical dissection of the link between Streptozotocin, O-GlcNAc and pancreatic cell death [Clostridium perfringens],2X0Y_A Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds [Clostridium perfringens],2X0Y_B Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds [Clostridium perfringens] |
| 5OXD_A | 2.50e-78 | 51 | 564 | 15 | 512 | Complexof a C. perfringens O-GlcNAcase with a fragment hit [Clostridium perfringens] |
| 2J62_A | 2.75e-78 | 51 | 564 | 13 | 510 | Structureof a bacterial O-glcnacase in complex with glcnacstatin [Clostridium perfringens],2J62_B Structure of a bacterial O-glcnacase in complex with glcnacstatin [Clostridium perfringens],2WB5_A GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation [Clostridium perfringens],2WB5_B GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation [Clostridium perfringens] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| Q0TR53 | 1.16e-80 | 11 | 785 | 3 | 746 | O-GlcNAcase NagJ OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) OX=195103 GN=nagJ PE=1 SV=1 |
| Q8XL08 | 1.58e-80 | 11 | 785 | 3 | 746 | O-GlcNAcase NagJ OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=nagJ PE=1 SV=1 |
| Q89ZI2 | 1.19e-63 | 159 | 800 | 111 | 733 | O-GlcNAcase BT_4395 OS=Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) OX=226186 GN=BT_4395 PE=1 SV=1 |
| Q2CEE3 | 2.27e-38 | 198 | 531 | 2 | 354 | Protein O-GlcNAcase OS=Oceanicola granulosus (strain ATCC BAA-861 / DSM 15982 / KCTC 12143 / HTCC2516) OX=314256 GN=OG2516_04129 PE=1 SV=1 |
| P26831 | 9.90e-34 | 158 | 799 | 142 | 794 | Hyaluronoglucosaminidase OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=nagH PE=1 SV=2 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.000498 | 0.998538 | 0.000242 | 0.000270 | 0.000231 | 0.000180 |