D-ribitol-5-phosphate cytidylyltransferase.

CDP-ME synthetase is involved in mevalonate-independent isoprenoid production. 4-diphosphocytidyl-2-methyl-D-erythritol synthase (CDP-ME), also called 2C-methyl-d-erythritol 4-phosphate cytidylyltransferase catalyzes the third step in the alternative (non-mevalonate) pathway of Isopentenyl diphosphate (IPP) biosynthesis: the formation of 4-diphosphocytidyl-2C-methyl-D-erythritol from CTP and 2C-methyl-D-erythritol 4-phosphate. This mevalonate independent pathway that utilizes pyruvate and glyceraldehydes 3-phosphate as starting materials for production of IPP occurs in a variety of bacteria, archaea and plant cells, but is absent in mammals. Thus, CDP-ME synthetase is an attractive targets for the structure-based design of selective antibacterial, herbicidal and antimalarial drugs.

Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are highly branched regions in pectic polysaccharides, consisting of repeating -(1,2)-L-Rha-(1,4)-D-GalUA disaccharide units, with many rhamnose residues substituted by neutral oligosaccharides such as arabinans, galactans and arabinogalactans. Extracellular enzymes participating in the degradation of plant cell wall polymers, such as Rhamnogalacturonan acetylesterase, would typically be found in saprophytic and plant pathogenic fungi and bacteria.

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. Members of this protein family are 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, the IspD protein of the deoxyxylulose pathway of IPP biosynthesis. In about twenty percent of bacterial genomes, this protein occurs as IspDF, a bifunctional fusion protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [Lipid transport and metabolism].

Crystalstructure of IspD from Bacillus subtilis at 1.80 Angstroms resolution, crystal form I [Bacillus subtilis subsp. subtilis str. 168],5DDT_B Crystal structure of IspD from Bacillus subtilis at 1.80 Angstroms resolution, crystal form I [Bacillus subtilis subsp. subtilis str. 168],5DDV_A Crystal structure of IspD from Bacillus subtilis at 2.30 Angstroms resolution, crystal form II [Bacillus subtilis subsp. subtilis str. 168],5HS2_A Crystal structure of IspD complexed with CTP and Mg2+ from Bacillus subtilis at 1.90 Angstroms resolution [Bacillus subtilis subsp. subtilis str. 168],5HS2_B Crystal structure of IspD complexed with CTP and Mg2+ from Bacillus subtilis at 1.90 Angstroms resolution [Bacillus subtilis subsp. subtilis str. 168]

Thecrystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritolsynthase from Anaerococcus prevotii DSM 20548 [Anaerococcus prevotii DSM 20548],4KT7_B The crystal structure of 4-diphosphocytidyl-2C-methyl-D-erythritolsynthase from Anaerococcus prevotii DSM 20548 [Anaerococcus prevotii DSM 20548]

2C-methyl-D-erythritol4-phosphate cytidylyltransferase (IspD) from Arabidopsis thaliana [Arabidopsis thaliana],4NAI_A Arabidopsis thaliana IspD apo [Arabidopsis thaliana]

Arabidopsisthaliana IspD Glu258Ala Mutant [Arabidopsis thaliana],5MRO_A Arabidopsis thaliana IspD Glu258Ala mutant in complex with Azolopyrimidine (1) [Arabidopsis thaliana],5MRP_A Arabidopsis thaliana IspD Glu258Ala mutant in complex with Azolopyrimidine (2) [Arabidopsis thaliana]

Inhibitorsof herbicidal target IspD [Arabidopsis thaliana]

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase OS=Lachnospira eligens (strain ATCC 27750 / DSM 3376 / VPI C15-48 / C15-B4) OX=515620 GN=ispD PE=3 SV=1

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase OS=Lachnoclostridium phytofermentans (strain ATCC 700394 / DSM 18823 / ISDg) OX=357809 GN=ispD PE=3 SV=1

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase OS=Clostridium kluyveri (strain NBRC 12016) OX=583346 GN=ispD PE=3 SV=1

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase OS=Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) OX=431943 GN=ispD PE=3 SV=1

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase OS=Clostridium perfringens (strain SM101 / Type A) OX=289380 GN=ispD PE=3 SV=1