ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. Ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. In most cases, ligands are monosaccharide including lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the domain sugar binding changes the DNA binding activity of the repressor domain.

DNA-binding transcriptional regulator, LacI/PurR family [Transcription].

Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.

GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms].

ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. This group includes the ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.

ChainA, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXB_B Chain B, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)']

ChainA, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXC_B Chain B, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXC_C Chain C, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXC_D Chain D, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)']

ChainA, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_B Chain B, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_C Chain C, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_D Chain D, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_E Chain E, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_F Chain F, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)']

Crystalstructure of a fusion protein containing the leucine zipper of GCN4 and the GGDEF domain of WspR from Pseudomonas aeruginosa [Saccharomyces cerevisiae],3I5C_B Crystal structure of a fusion protein containing the leucine zipper of GCN4 and the GGDEF domain of WspR from Pseudomonas aeruginosa [Saccharomyces cerevisiae]

SadC(300-487) from Pseudomonas aeruginosa PAO1 [Pseudomonas aeruginosa PAO1],4WXO_B SadC (300-487) from Pseudomonas aeruginosa PAO1 [Pseudomonas aeruginosa PAO1],4WXO_C SadC (300-487) from Pseudomonas aeruginosa PAO1 [Pseudomonas aeruginosa PAO1]

HTH-type transcriptional repressor PurR OS=Vibrio atlanticus (strain LGP32) OX=575788 GN=purR PE=3 SV=1

HTH-type transcriptional repressor PurR OS=Photobacterium profundum (strain SS9) OX=298386 GN=purR PE=3 SV=2

HTH-type transcriptional repressor CytR OS=Escherichia coli O157:H7 OX=83334 GN=cytR PE=3 SV=1

HTH-type transcriptional repressor CytR OS=Escherichia coli (strain K12) OX=83333 GN=cytR PE=1 SV=1

HTH-type transcriptional repressor CytR OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) OX=199310 GN=cytR PE=3 SV=1