trehalose synthase-fused probable maltokinase. Three pathways for the biosynthesis of trehalose, an osmoprotectant that in some species is also a precursor of certain cell wall glycolipids. Trehalose synthase, TreS, can interconvert maltose and trehalose, but while the equilibrium may favor trehalose, physiological concentrations of trehalose may be much greater than that of maltose and TreS may act largely in its degradation. This model describes a domain found only as a C-terminal fusion to TreS proteins. The most closely related proteins outside this family, Pep2 of Streptomyces coelicolor and Mak1 of Actinoplanes missouriensis, have known maltokinase activity. We suggest this domain acts as a maltokinase and helps drive conversion of trehalose to maltose. [Energy metabolism, Biosynthesis and degradation of polysaccharides]

Predicted trehalose synthase [Carbohydrate transport and metabolism].

glycogen branching enzyme; Provisional

Type II Homoserine Kinase. This subfamily is composed of unusual homoserine kinases, from a subset of bacteria, which have a Protein Kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to L-homoserine producing L-homoserine phosphate, an intermediate in the production of the amino acids threonine, methionine, and isoleucine. The Type II homoserine kinase subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).

ChainA, Maltokinase [Mycobacterium tuberculosis],4O7O_B Chain B, Maltokinase [Mycobacterium tuberculosis],4O7P_A Chain A, Maltokinase [Mycobacterium tuberculosis],4O7P_B Chain B, Maltokinase [Mycobacterium tuberculosis]

Structureof mycobacterial maltokinase, the missing link in the essential GlgE-pathway [Mycolicibacterium vanbaalenii PYR-1],4U98_A Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (AppCp complex) [Mycolicibacterium vanbaalenii PYR-1],4WZY_A Structure of mycobacterial maltokinase, the missing link in the essential GlgE-pathway (ATP complex) [Mycolicibacterium vanbaalenii PYR-1]

Complexof Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_J Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_K Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_L Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_M Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_N Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_O Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155],5JY7_P Complex of Mycobacterium smegmatis trehalose synthase with maltokinase [Mycolicibacterium smegmatis MC2 155]

Glucosaminekinase (crystal form A) [Streptacidiphilus jiangxiensis],6HWJ_B Glucosamine kinase (crystal form A) [Streptacidiphilus jiangxiensis],6HWK_A Glucosamine kinase (crystal form B) [Streptacidiphilus jiangxiensis],6HWK_B Glucosamine kinase (crystal form B) [Streptacidiphilus jiangxiensis],6HWK_C Glucosamine kinase (crystal form B) [Streptacidiphilus jiangxiensis],6HWK_D Glucosamine kinase (crystal form B) [Streptacidiphilus jiangxiensis],6HWL_A Glucosamine kinase in complex with glucosamine, ADP and inorganic phosphate [Streptacidiphilus jiangxiensis],6HWL_B Glucosamine kinase in complex with glucosamine, ADP and inorganic phosphate [Streptacidiphilus jiangxiensis]

Maltokinase OS=Mycobacterium marinum (strain ATCC BAA-535 / M) OX=216594 GN=mak PE=3 SV=1

Maltokinase OS=Actinoplanes missouriensis OX=1866 GN=mak1 PE=1 SV=1

Maltokinase OS=Mycobacterium ulcerans (strain Agy99) OX=362242 GN=mak PE=3 SV=1

Maltokinase OS=Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) OX=262316 GN=mak PE=3 SV=1

Maltokinase OS=Mycobacterium avium (strain 104) OX=243243 GN=mak PE=3 SV=1