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CAZyme Information: MGYG000001453_01838
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Aneurinibacillus aneurinilyticus | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Firmicutes; Bacilli; Aneurinibacillales; Aneurinibacillaceae; Aneurinibacillus; Aneurinibacillus aneurinilyticus | |||||||||||
| CAZyme ID | MGYG000001453_01838 | |||||||||||
| CAZy Family | GT2 | |||||||||||
| CAZyme Description | Gramicidin S synthase 1 | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 5512; End: 8781 Strand: + | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| PRK05691 | PRK05691 | 0.0 | 10 | 1078 | 2168 | 3245 | peptide synthase; Validated |
| PRK12316 | PRK12316 | 0.0 | 10 | 1078 | 3037 | 4090 | peptide synthase; Provisional |
| PRK12467 | PRK12467 | 0.0 | 20 | 786 | 503 | 1290 | peptide synthase; Provisional |
| PRK12467 | PRK12467 | 0.0 | 10 | 1078 | 1554 | 2634 | peptide synthase; Provisional |
| cd12117 | A_NRPS_Srf_like | 0.0 | 34 | 514 | 1 | 483 | The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C). The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QND46664.1 | 3.32e-144 | 20 | 916 | 999 | 1915 |
| BAZ00088.1 | 6.85e-126 | 10 | 595 | 559 | 1174 |
| BAZ75991.1 | 6.85e-126 | 10 | 595 | 559 | 1174 |
| BAY30132.1 | 8.31e-124 | 10 | 595 | 559 | 1176 |
| BAY90071.1 | 1.82e-121 | 7 | 606 | 553 | 1184 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 1AMU_A | 0.0 | 1 | 547 | 1 | 556 | PhenylalanineActivating Domain Of Gramicidin Synthetase 1 In A Complex With Amp And Phenylalanine [Brevibacillus brevis],1AMU_B Phenylalanine Activating Domain Of Gramicidin Synthetase 1 In A Complex With Amp And Phenylalanine [Brevibacillus brevis] |
| 5ISW_A | 0.0 | 529 | 1089 | 2 | 562 | Structureof the apo PCP-E didomain of the gramicidin S synthetase A [Brevibacillus brevis],5ISX_A Structure of the holo PCP-E didomain of the gramicidin S synthetase A [Brevibacillus brevis],5ISX_B Structure of the holo PCP-E didomain of the gramicidin S synthetase A [Brevibacillus brevis] |
| 2XHG_A | 5.03e-198 | 604 | 1056 | 7 | 459 | CrystalStructure of the Epimerization Domain from the Initiation Module of Tyrocidine Biosynthesis [Brevibacillus brevis] |
| 5M6P_A | 2.22e-190 | 602 | 1082 | 22 | 494 | CrystalStructure of the Epimerization Domain from Module 3 of Tyrocidine Synthetase B, TycB3(E) [Brevibacillus parabrevis],5M6P_B Crystal Structure of the Epimerization Domain from Module 3 of Tyrocidine Synthetase B, TycB3(E) [Brevibacillus parabrevis],6TA8_A Chain A, Tyrocidine synthase 2 [Brevibacillus parabrevis],6TA8_B Chain B, Tyrocidine synthase 2 [Brevibacillus parabrevis] |
| 5N82_A | 3.98e-181 | 26 | 420 | 33 | 427 | Crystalstructure of an engineered TycA variant in complex with an beta-Phe-AMP analog [Brevibacillus parabrevis] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P0C062 | 0.0 | 1 | 1089 | 1 | 1098 | Gramicidin S synthase 1 OS=Brevibacillus brevis OX=1393 GN=grsA PE=1 SV=1 |
| P09095 | 0.0 | 26 | 1088 | 23 | 1087 | Tyrocidine synthase 1 OS=Brevibacillus parabrevis OX=54914 GN=tycA PE=1 SV=2 |
| P0C061 | 0.0 | 1 | 1089 | 1 | 1098 | Gramicidin S synthase 1 OS=Aneurinibacillus migulanus OX=47500 GN=grsA PE=1 SV=1 |
| O30408 | 0.0 | 11 | 1082 | 2525 | 3585 | Tyrocidine synthase 2 OS=Brevibacillus parabrevis OX=54914 GN=tycB PE=1 SV=1 |
| Q9R9I9 | 4.64e-307 | 20 | 1078 | 251 | 1310 | Mycosubtilin synthase subunit C OS=Bacillus subtilis OX=1423 GN=mycC PE=3 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000072 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |