dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000002082_00719

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Basic Information help

Species

Alistipes sp900544265

Lineage

Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Alistipes sp900544265

CAZyme ID

MGYG000002082_00719

CAZy Family

GH38

CAZyme Description

hypothetical protein

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
863	MGYG000002082_3\|CGC3	96199.33	6.6261

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000002082	2573115	MAG	Netherlands	Europe

Gene Location

Start: 174322; End: 176913 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000002082_00719.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GH38	59	204	1.2e-29	0.5278810408921933

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0383	AMS1	3.12e-20	119	863	286	943	Alpha-mannosidase [Carbohydrate transport and metabolism].
pfam07748	Glyco_hydro_38C	1.12e-11	502	707	1	182	Glycosyl hydrolases family 38 C-terminal domain. Glycosyl hydrolases are key enzymes of carbohydrate metabolism.
PRK09819	PRK09819	3.73e-11	459	829	452	847	mannosylglycerate hydrolase.
cd10789	GH38N_AMII_ER_cytosolic	1.48e-10	60	201	32	169	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38). The subfamily is represented by Saccharomyces cerevisiae vacuolar alpha-mannosidase Ams1, rat ER/cytosolic alpha-mannosidase Man2C1, and similar proteins. Members in this family share high sequence similarity. None of them have any classical signal sequence or membrane spanning domains, which are typical of sorting or targeting signals. Ams1 functions as a second resident vacuolar hydrolase in S. cerevisiae. It aids in recycling macromolecular components of the cell through hydrolysis of terminal, non-reducing alpha-d-mannose residues. Ams1 utilizes both the cytoplasm to vacuole targeting (Cvt, nutrient-rich conditions) and autophagic (starvation conditions) pathways for biosynthetic delivery to the vacuole. Man2C1is involved in oligosaccharide catabolism in both the ER and cytosol. It can catalyze the cobalt-dependent cleavage of alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues. Members in this family are retaining glycosyl hydrolases of family GH38 that employs a two-step mechanism involving the formation of a covalent glycosyl-enzyme complex. Two carboxylic acids positioned within the active site act in concert: one as a catalytic nucleophile and the other as a general acid/base catalyst.
pfam01074	Glyco_hydro_38	3.81e-10	60	169	32	140	Glycosyl hydrolases family 38 N-terminal domain. Glycosyl hydrolases are key enzymes of carbohydrate metabolism.

CAZyme Hits help

Hit ID	Query Start	Query End	Hit Start	Hit End
BBL11622.1	2	863	24	883
BBL08830.1	2	863	24	883
BBL00893.1	2	863	24	882
BBL06663.1	16	863	34	880
QUR41760.1	22	862	7	852

PDB Hits help

has no PDB hit.

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q9NTJ4	1.16e-10	55	820	280	994	Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1
Q91W89	5.25e-09	55	820	279	993	Alpha-mannosidase 2C1 OS=Mus musculus OX=10090 GN=Man2c1 PE=1 SV=1
P21139	1.60e-06	55	820	279	994	Alpha-mannosidase 2C1 OS=Rattus norvegicus OX=10116 GN=Man2c1 PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as SP

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000407	0.998830	0.000241	0.000193	0.000165	0.000147

TMHMM Annotations download full data without filtering help

start	end
13	32