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CAZyme Information: MGYG000002300_01425
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Bacteroides cutis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Bacteroides cutis | |||||||||||
| CAZyme ID | MGYG000002300_01425 | |||||||||||
| CAZy Family | GH29 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 100697; End: 102142 Strand: + | |||||||||||
CAZyme Signature Domains help
| Family | Start | End | Evalue | family coverage |
|---|---|---|---|---|
| GH29 | 45 | 381 | 6.8e-92 | 0.8959537572254336 |
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| smart00812 | Alpha_L_fucos | 3.93e-131 | 33 | 419 | 2 | 383 | Alpha-L-fucosidase. O-Glycosyl hydrolases (EC 3.2.1.-) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in 'clans'. Family 29 encompasses alpha-L-fucosidases, which is a lysosomal enzyme responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. Deficiency of alpha-L-fucosidase results in the lysosomal storage disease fucosidosis. |
| pfam01120 | Alpha_L_fucos | 1.10e-95 | 54 | 377 | 22 | 333 | Alpha-L-fucosidase. |
| COG3669 | AfuC | 1.03e-34 | 64 | 381 | 1 | 321 | Alpha-L-fucosidase [Carbohydrate transport and metabolism]. |
| pfam14871 | GHL6 | 1.44e-06 | 111 | 188 | 1 | 77 | Hypothetical glycosyl hydrolase 6. GHL6 is a family of hypothetical glycoside hydrolases. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QUT89584.1 | 7.61e-301 | 3 | 481 | 14 | 491 |
| ALJ59359.1 | 7.61e-301 | 3 | 481 | 14 | 491 |
| QCQ35262.1 | 1.99e-289 | 1 | 481 | 1 | 472 |
| QCQ48665.1 | 5.69e-289 | 1 | 481 | 1 | 472 |
| QTO26657.1 | 5.69e-289 | 1 | 481 | 1 | 472 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 4JL2_A | 1.75e-288 | 33 | 481 | 1 | 450 | Crystalstructure of a bacterial fucosidase with a monovalent iminocyclitol inhibitor [Bacteroides thetaiotaomicron VPI-5482],4JL2_B Crystal structure of a bacterial fucosidase with a monovalent iminocyclitol inhibitor [Bacteroides thetaiotaomicron VPI-5482] |
| 2XIB_A | 1.96e-288 | 30 | 481 | 1 | 453 | CrystalStructure Of An Alpha-L-Fucosidase Gh29 From Bacteroides Thetaiotaomicron In Complex With Deoxyfuconojirimycin [Bacteroides thetaiotaomicron],2XIB_B Crystal Structure Of An Alpha-L-Fucosidase Gh29 From Bacteroides Thetaiotaomicron In Complex With Deoxyfuconojirimycin [Bacteroides thetaiotaomicron],2XIB_C Crystal Structure Of An Alpha-L-Fucosidase Gh29 From Bacteroides Thetaiotaomicron In Complex With Deoxyfuconojirimycin [Bacteroides thetaiotaomicron],2XIB_D Crystal Structure Of An Alpha-L-Fucosidase Gh29 From Bacteroides Thetaiotaomicron In Complex With Deoxyfuconojirimycin [Bacteroides thetaiotaomicron],2XII_A Crystal Structure Of An Alpha-L-Fucosidase Gh29 From Bacteroides Thetaiotaomicron In Complex With An Extended 9- Fluorenone Iminosugar Inhibitor [Bacteroides thetaiotaomicron],2XII_B Crystal Structure Of An Alpha-L-Fucosidase Gh29 From Bacteroides Thetaiotaomicron In Complex With An Extended 9- Fluorenone Iminosugar Inhibitor [Bacteroides thetaiotaomicron] |
| 2WVV_B | 2.49e-288 | 33 | 481 | 1 | 450 | Crystalstructure of an alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482] |
| 2WVV_A | 2.49e-288 | 33 | 481 | 1 | 450 | Crystalstructure of an alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482],2WVV_C Crystal structure of an alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482],2WVV_D Crystal structure of an alpha-L-fucosidase GH29 from Bacteroides thetaiotaomicron [Bacteroides thetaiotaomicron VPI-5482],4J27_A Crystal structure of a gh29 alpha-l-fucosidase gh29 from bacteroides thetaiotaomicron in a novel crystal form [Bacteroides thetaiotaomicron VPI-5482],4J27_B Crystal structure of a gh29 alpha-l-fucosidase gh29 from bacteroides thetaiotaomicron in a novel crystal form [Bacteroides thetaiotaomicron VPI-5482],4J28_A Crystal structure of a gh29 alpha-l-fucosidase gh29 from bacteroides thetaiotaomicron in complex with a 5-membered iminocyclitol inhibitor [Bacteroides thetaiotaomicron VPI-5482],4J28_B Crystal structure of a gh29 alpha-l-fucosidase gh29 from bacteroides thetaiotaomicron in complex with a 5-membered iminocyclitol inhibitor [Bacteroides thetaiotaomicron VPI-5482],4JFS_A Crystal structure of a bacterial fucosidase with iminosugar inhibitor 4-epi-(+)-Codonopsinine [Bacteroides thetaiotaomicron VPI-5482],4JFS_B Crystal structure of a bacterial fucosidase with iminosugar inhibitor 4-epi-(+)-Codonopsinine [Bacteroides thetaiotaomicron VPI-5482],4JFT_A Crystal structure of a bacterial fucosidase with iminosugar inhibitor N-desmethyl-4-epi-(+)-Codonopsinine [Bacteroides thetaiotaomicron VPI-5482],4JFT_B Crystal structure of a bacterial fucosidase with iminosugar inhibitor N-desmethyl-4-epi-(+)-Codonopsinine [Bacteroides thetaiotaomicron VPI-5482],4JFU_A Crystal structure of a bacterial fucosidase with iminosugar inhibitor [Bacteroides thetaiotaomicron VPI-5482],4JFU_B Crystal structure of a bacterial fucosidase with iminosugar inhibitor [Bacteroides thetaiotaomicron VPI-5482],4JFV_A Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(methylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol [Bacteroides thetaiotaomicron VPI-5482],4JFV_B Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(methylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol [Bacteroides thetaiotaomicron VPI-5482],4JFV_C Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(methylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol [Bacteroides thetaiotaomicron VPI-5482],4JFV_D Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(methylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol [Bacteroides thetaiotaomicron VPI-5482],4JFW_A Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(propylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol [Bacteroides thetaiotaomicron VPI-5482],4JFW_B Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(propylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol [Bacteroides thetaiotaomicron VPI-5482],4JFW_C Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(propylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol [Bacteroides thetaiotaomicron VPI-5482],4JFW_D Crystal structure of a bacterial fucosidase with iminosugar inhibitor (2S,3S,4R,5S)-2-[N-(propylferrocene)]aminoethyl-5-methylpyrrolidine-3,4-diol [Bacteroides thetaiotaomicron VPI-5482],4JL1_A Crystal structure of a bacterial fucosidase with a multivalent iminocyclitol inhibitor [Bacteroides thetaiotaomicron VPI-5482],4JL1_B Crystal structure of a bacterial fucosidase with a multivalent iminocyclitol inhibitor [Bacteroides thetaiotaomicron VPI-5482] |
| 6HZY_A | 4.48e-288 | 30 | 481 | 23 | 475 | Crystalstructure of a bacterial fucosidase with inhibitor FucPUG [Bacteroides thetaiotaomicron VPI-5482],6HZY_B Crystal structure of a bacterial fucosidase with inhibitor FucPUG [Bacteroides thetaiotaomicron VPI-5482] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P17164 | 2.82e-42 | 52 | 474 | 47 | 462 | Tissue alpha-L-fucosidase OS=Rattus norvegicus OX=10116 GN=Fuca1 PE=1 SV=1 |
| C3YWU0 | 7.94e-41 | 54 | 453 | 34 | 429 | Alpha-L-fucosidase OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_56888 PE=3 SV=2 |
| P04066 | 3.71e-39 | 54 | 456 | 53 | 449 | Tissue alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA1 PE=1 SV=4 |
| Q60HF8 | 7.29e-39 | 54 | 456 | 55 | 451 | Tissue alpha-L-fucosidase OS=Macaca fascicularis OX=9541 GN=FUCA1 PE=2 SV=1 |
| Q99LJ1 | 7.72e-39 | 54 | 456 | 39 | 435 | Tissue alpha-L-fucosidase OS=Mus musculus OX=10090 GN=Fuca1 PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as SP
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 0.008042 | 0.974509 | 0.016035 | 0.000512 | 0.000425 | 0.000456 |