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CAZyme Information: MGYG000002471_02654
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Basic Information |
Genomic context |
Full Sequence |
Enzyme annotations |
CAZy signature domains |
CDD domains |
CAZyme hits |
PDB hits |
Swiss-Prot hits |
SignalP and Lipop annotations |
TMHMM annotations
Basic Information help
| Species | Yersinia mollaretii | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lineage | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Yersinia; Yersinia mollaretii | |||||||||||
| CAZyme ID | MGYG000002471_02654 | |||||||||||
| CAZy Family | GT44 | |||||||||||
| CAZyme Description | hypothetical protein | |||||||||||
| CAZyme Property |
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| Genome Property |
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| Gene Location | Start: 131711; End: 137716 Strand: - | |||||||||||
CDD Domains download full data without filtering help
| Cdd ID | Domain | E-Value | qStart | qEnd | sStart | sEnd | Domain Description |
|---|---|---|---|---|---|---|---|
| cd20502 | C80_toxinA_B-like | 1.25e-92 | 556 | 765 | 1 | 209 | Peptidase C80 cysteine binding domain of Clostridium difficile toxins A and B, and related proteins. This peptidase C80 family includes the major virulence factors of Clostridium difficile multidomain toxins TcdA and TcdB. These large homologous toxins contain several distinct domains including a cysteine protease domain (CPD) that autoproteolytically releases a cytotoxic effector domain upon binding of intracellular inositol hexakisphosphate. C. difficile is a major cause of intestinal tissue damage and inflammation, and TcdA is generally more inflammatory whereas TcdB is more cytotoxic; studies show that the CPD is an internal regulator of the proinflammatory activity. Site-directed mutagenesis has identified functional residues Asp/His/Cys in Clostridium toxin B. |
| pfam12920 | TcdA_TcdB_pore | 2.55e-65 | 844 | 1369 | 7 | 524 | TcdA/TcdB pore forming domain. This family represents the most conserved region within the C. difficile Toxin A and Toxin B pore forming region. |
| pfam12919 | TcdA_TcdB | 7.30e-29 | 18 | 395 | 2 | 382 | TcdA/TcdB catalytic glycosyltransferase domain. This domain represents the N-terminal glycosyltransferase from a set of toxins found in some bacteria. This domain in TcdB glycosylates the host RhoA protein. |
| pfam11713 | Peptidase_C80 | 5.51e-20 | 554 | 729 | 1 | 152 | Peptidase C80 family. This family belongs to cysteine peptidase family C80. |
| cd20500 | Peptidase_C80 | 3.44e-14 | 557 | 729 | 1 | 150 | peptidase C80 family. The peptidase C80 family includes self-cleaving proteins that are precursors of bacterial toxins such as the Vibrio cholerae RTX self-cleaving toxin, as well as the major virulence factors of Clostridium difficile multidomain toxins, TcdA and TcdB. These toxins contain a cysteine protease domain (CPD) that autoproteolytically releases a cytotoxic effector domain upon binding intracellular inositol hexakisphosphate. This family also contains filamentous hemagglutinin family cysteine protease C80 domains, that are located at the C-terminus. All domains in this family contain the characteristic Cys/His residues in the active site. Site-directed mutagenesis has identified functional residues Asp/His/Cys in Clostridium toxin B and His/Cys in cholera RTX toxin. |
CAZyme Hits help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End |
|---|---|---|---|---|---|
| QKJ02298.1 | 0.0 | 1 | 2001 | 1 | 1994 |
| EEQ09150.1 | 0.0 | 1 | 2001 | 1 | 1994 |
| CDF47254.1 | 8.80e-91 | 9 | 1435 | 87 | 1435 |
| AXU26653.1 | 1.38e-90 | 9 | 1435 | 87 | 1435 |
| AXU34300.1 | 1.38e-90 | 9 | 1435 | 87 | 1435 |
PDB Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| 6RTG_A | 1.47e-259 | 2 | 518 | 3 | 517 | Crystalstructure of the UDP-bound glycosyltransferase domain from the YGT toxin [Yersinia mollaretii ATCC 43969],6RTH_A Crystal structure of the ligand-free glycosyltransferase domain from the YGT toxin [Yersinia mollaretii ATCC 43969],6RTH_B Crystal structure of the ligand-free glycosyltransferase domain from the YGT toxin [Yersinia mollaretii ATCC 43969] |
| 4R04_A | 6.06e-92 | 9 | 1435 | 87 | 1435 | ChainA, Toxin A [Clostridioides difficile] |
| 7POG_A | 8.72e-92 | 9 | 1435 | 87 | 1435 | ChainA, Toxin A [Clostridioides difficile] |
| 7V1N_A | 9.61e-81 | 5 | 1431 | 84 | 1431 | ChainA, Toxin B [Clostridioides difficile] |
| 6AR6_A | 9.14e-78 | 10 | 1394 | 84 | 1389 | ChainA, Toxin B [Clostridioides difficile] |
Swiss-Prot Hits download full data without filtering help
| Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
|---|---|---|---|---|---|---|
| P16154 | 8.24e-91 | 9 | 1435 | 87 | 1435 | Toxin A OS=Clostridioides difficile OX=1496 GN=tcdA PE=1 SV=2 |
| T0D3N5 | 1.95e-83 | 10 | 1393 | 87 | 1391 | Cytotoxin-L OS=Paeniclostridium sordellii (strain ATCC 9714 / DSM 2141 / JCM 3814 / LMG 15708 / NCIMB 10717 / 211) OX=1292036 GN=tcsL PE=1 SV=1 |
| Q46342 | 3.37e-83 | 10 | 1393 | 87 | 1391 | Cytotoxin-L OS=Paeniclostridium sordellii OX=1505 GN=tcsL PE=1 SV=1 |
| P0DUB4 | 2.00e-81 | 10 | 1393 | 87 | 1391 | Cytotoxin-L OS=Paeniclostridium sordellii OX=1505 GN=tcsL PE=1 SV=1 |
| Q9EXR0 | 3.51e-79 | 5 | 1431 | 84 | 1431 | Toxin B OS=Clostridioides difficile OX=1496 GN=tcdB PE=1 SV=1 |
SignalP and Lipop Annotations help
This protein is predicted as OTHER
| Other | SP_Sec_SPI | LIPO_Sec_SPII | TAT_Tat_SPI | TATLIP_Sec_SPII | PILIN_Sec_SPIII |
|---|---|---|---|---|---|
| 1.000082 | 0.000000 | 0.000000 | 0.000000 | 0.000000 | 0.000000 |