A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.

Stealth protein CR2, conserved region 2. Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.

Glycosyl transferase family 8. This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis].

Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.

ChainA, WbbM protein [Klebsiella pneumoniae]

ChainA, FI02838p [Drosophila melanogaster],7DXI_B Chain B, FI02838p [Drosophila melanogaster]

ChainA, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [Homo sapiens],7S05_B Chain B, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [Homo sapiens],7S06_A Chain A, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [Homo sapiens],7S06_B Chain B, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [Homo sapiens]

ChainA, alpha-1,4-galactosyl transferase [Neisseria meningitidis]

Capsular polysaccharide phosphotransferase fcs1 OS=Haemophilus influenzae OX=727 GN=fcs1 PE=3 SV=1

Capsular polysaccharide phosphotransferase LcbA OS=Aeromonas hydrophila OX=644 GN=lcbA PE=3 SV=1

Capsular polysaccharide phosphotransferase LcbA OS=Aeromonas hydrophila OX=644 GN=lcbA PE=3 SV=1

Capsular polysaccharide phosphotransferase OS=Neisseria meningitidis serogroup B OX=491 PE=3 SV=1

Capsular polysaccharide phosphotransferase cps1A OS=Actinobacillus pleuropneumoniae OX=715 GN=cps1A PE=3 SV=1