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CAZyme Information: MGYG000002872_02492

You are here: Home > Sequence: MGYG000002872_02492

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species UMGS874 sp900546315
Lineage Bacteria; Firmicutes_A; Clostridia; Oscillospirales; CAG-272; UMGS874; UMGS874 sp900546315
CAZyme ID MGYG000002872_02492
CAZy Family PL21
CAZyme Description Heparin and heparin-sulfate lyase
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
733 81172.09 4.4695
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000002872 3007809 MAG United States North America
Gene Location Start: 257;  End: 2458  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

No EC number prediction in MGYG000002872_02492.

CAZyme Signature Domains help

Family Start End Evalue family coverage
PL21 386 452 8e-22 0.9722222222222222

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
pfam07940 Hepar_II_III 1.67e-06 378 586 12 189
Heparinase II/III-like protein. This family features sequences that are similar to a region of the Flavobacterium heparinum proteins heparinase II and heparinase III. The former is known to degrade heparin and heparin sulphate, whereas the latter predominantly degrades heparin sulphate. Both are secreted into the periplasmic space upon induction with heparin.
pfam18675 HepII_C 0.001 653 730 1 86
Heparinase II C-terminal domain. Heparinase II (HepII) is an 85-kDa dimeric enzyme that depolymerizes both heparin and heparan sulfate glycosaminoglycans. The protein is composed of three domains: an N-terminal alpha-helical domain, a central two-layered beta-sheet domain, and a C-terminal domain forming a two-layered beta-sheet. The C-terminal domain contains nine beta-strands packed together in a manner resembling a beta-barrel.

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
BCI63941.1 9.58e-176 33 730 43 789
BCI63940.1 1.29e-165 33 728 47 789
BBH20141.1 1.74e-136 21 705 228 925
QOU74174.1 2.57e-126 24 730 182 938
QUT43394.1 2.07e-125 33 705 45 747

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
2FUQ_A 9.18e-122 33 732 23 747
ChainA, heparinase II protein [Pedobacter heparinus],2FUQ_B Chain B, heparinase II protein [Pedobacter heparinus]
3E80_A 9.67e-122 33 732 25 749
Structureof Heparinase II complexed with heparan sulfate degradation disaccharide product [Pedobacter heparinus],3E80_B Structure of Heparinase II complexed with heparan sulfate degradation disaccharide product [Pedobacter heparinus],3E80_C Structure of Heparinase II complexed with heparan sulfate degradation disaccharide product [Pedobacter heparinus]
3E7J_A 6.11e-119 33 732 25 749
ChainA, Heparinase II protein [Pedobacter heparinus],3E7J_B Chain B, Heparinase II protein [Pedobacter heparinus]
2FUT_A 9.60e-117 33 732 24 748
ChainA, heparinase II protein [Pedobacter heparinus],2FUT_B Chain B, heparinase II protein [Pedobacter heparinus]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
C6XZB6 9.62e-121 33 732 48 772
Heparin and heparin-sulfate lyase OS=Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3) OX=485917 GN=hepB PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
1.000044 0.000000 0.000000 0.000000 0.000000 0.000000

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000002872_02492.