ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. Ligand binding domain of the LacI transcriptional regulator family belonging to the type 1 periplasmic-binding fold protein superfamily. In most cases, ligands are monosaccharide including lactose, ribose, fructose, xylose, arabinose, galactose/glucose, and other sugars. The LacI family of proteins consists of transcriptional regulators related to the lac repressor. In this case, the domain sugar binding changes the DNA binding activity of the repressor domain.

DNA-binding transcriptional regulator, LacI/PurR family [Transcription].

Diguanylate-cyclase (DGC) or GGDEF domain. Diguanylate-cyclase (DGC) or GGDEF domain: Originally named after a conserved residue pattern, and initially described as a domain of unknown function 1 (DUF1). This domain is widely present in bacteria, linked to a wide range of non-homologous domains in a variety of cell signaling proteins. The domain shows homology to the adenylyl cyclase catalytic domain. This correlates with the functional information available on two GGDEF-containing proteins, namely diguanylate cyclase and phosphodiesterase A of Acetobacter xylinum, both of which regulate the turnover of cyclic diguanosine monophosphate. Together with the EAL domain, GGDEF might be involved in regulating cell surface adhesion in bacteria.

GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants [Signal transduction mechanisms].

ligand-binding domain of putative DNA transcription regulators highly similar to that of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation. This group includes the ligand-binding domain of uncharacterized DNA transcription repressors highly similar to that of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation (CCR), a process in which enzymes necessary for the metabolism of alternative sugars are inhibited in the presence of glucose. In gram-positive bacteria, CCR is controlled by HPr, a phosphoenolpyruvate:sugar phsophotrasnferase system (PTS) and a transcriptional regulator CcpA. Moreover, CcpA can regulate sporulation and antibiotic resistance as well as play a role in virulence development of certain pathogens such as the group A streptococcus. The ligand binding domain of CcpA is a member of the LacI-GalR family of bacterial transcription regulators.

Crystalstructure of GGDEF domain of the E. coli DosC - form I (apo-form) [Escherichia coli K-12],4ZVF_A Crystal structure of GGDEF domain of the E. coli DosC - form II (GTP-alpha-S-bound) [Escherichia coli K-12],4ZVG_A Crystal structure of GGDEF domain of the E. coli DosC - form III [Escherichia coli K-12],4ZVG_B Crystal structure of GGDEF domain of the E. coli DosC - form III [Escherichia coli K-12],4ZVH_A Crystal structure of GGDEF domain of the E. coli DosC - form IV [Escherichia coli K-12],4ZVH_B Crystal structure of GGDEF domain of the E. coli DosC - form IV [Escherichia coli K-12]

ChainA, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXB_B Chain B, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)']

ChainA, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXC_B Chain B, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXC_C Chain C, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXC_D Chain D, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)']

Crystalstructure of a fusion protein containing the leucine zipper of GCN4 and the GGDEF domain of WspR from Pseudomonas aeruginosa [Saccharomyces cerevisiae],3I5C_B Crystal structure of a fusion protein containing the leucine zipper of GCN4 and the GGDEF domain of WspR from Pseudomonas aeruginosa [Saccharomyces cerevisiae]

ChainA, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_B Chain B, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_C Chain C, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_D Chain D, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_E Chain E, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)'],6ZXM_F Chain F, Putative GGDEF/response regulator receiver domain protein [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)']

HTH-type transcriptional repressor PurR OS=Vibrio atlanticus (strain LGP32) OX=575788 GN=purR PE=3 SV=1

HTH-type transcriptional repressor PurR OS=Photobacterium profundum (strain SS9) OX=298386 GN=purR PE=3 SV=2

HTH-type transcriptional repressor PurR OS=Vibrio vulnificus (strain CMCP6) OX=216895 GN=purR PE=3 SV=1

HTH-type transcriptional repressor PurR OS=Vibrio vulnificus (strain YJ016) OX=196600 GN=purR PE=3 SV=1

HTH-type transcriptional repressor CytR OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) OX=199310 GN=cytR PE=3 SV=1