dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000003791_00372

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Basic Information help

Species

Lineage

Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Brevibacteriaceae; Brevibacterium;

CAZyme ID

MGYG000003791_00372

CAZy Family

AA3

CAZyme Description

Oxygen-dependent choline dehydrogenase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
575	MGYG000003791_14\|CGC1	63073.99	6.137

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000003791	2144765	MAG	Canada	North America

Gene Location

Start: 2196; End: 3923 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000003791_00372.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
AA3	2	524	5.9e-151	0.9841549295774648

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
PRK02106	PRK02106	0.0	2	539	10	547	choline dehydrogenase; Validated
TIGR01810	betA	0.0	1	529	3	532	choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]
COG2303	BetA	1.04e-175	1	531	11	541	Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only].
TIGR03970	Rv0697	5.45e-88	1	524	4	487	dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function.
pfam00732	GMC_oxred_N	1.07e-46	68	292	15	218	GMC oxidoreductase. This family of proteins bind FAD as a cofactor.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
ANI26486.1	1.21e-158	1	538	74	616
AWP09430.1	4.30e-157	1	538	23	565
CAB3230510.1	4.05e-156	1	537	28	569
CAG5086058.1	9.43e-151	1	529	18	569
CAG5089487.1	4.55e-150	1	539	20	574

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3LJP_A	6.45e-78	1	527	17	534	ChainA, Choline oxidase [Arthrobacter globiformis],3LJP_B Chain B, Choline oxidase [Arthrobacter globiformis]
6ZH7_A	1.39e-77	1	529	11	566	ChainA, Fatty acid photodecarboxylase, chloroplastic [Chlorella variabilis],6ZH7_B Chain B, Fatty acid photodecarboxylase, chloroplastic [Chlorella variabilis]
6YRU_AAA	1.39e-77	1	529	11	566	ChainAAA, Fatty acid Photodecarboxylase [Chlorella variabilis],6YRV_AAA Chain AAA, Fatty acid Photodecarboxylase [Chlorella variabilis],6YRX_AAA Chain AAA, Fatty acid Photodecarboxylase [Chlorella variabilis],6YRZ_AAA Chain AAA, Fatty acid photodecarboxylase, chloroplastic [Chlorella variabilis]
6YS1_AAA	1.94e-77	1	529	11	566	ChainAAA, Fatty acid Photodecarboxylase [Chlorella variabilis]
5NCC_A	2.01e-77	1	529	27	582	Structureof Fatty acid Photodecarboxylase in complex with FAD and palmitic acid [Chlorella variabilis],5NCC_B Structure of Fatty acid Photodecarboxylase in complex with FAD and palmitic acid [Chlorella variabilis],5NCC_C Structure of Fatty acid Photodecarboxylase in complex with FAD and palmitic acid [Chlorella variabilis],5NCC_D Structure of Fatty acid Photodecarboxylase in complex with FAD and palmitic acid [Chlorella variabilis],5NCC_E Structure of Fatty acid Photodecarboxylase in complex with FAD and palmitic acid [Chlorella variabilis],5NCC_F Structure of Fatty acid Photodecarboxylase in complex with FAD and palmitic acid [Chlorella variabilis]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q9X2M2	2.66e-259	1	538	8	548	Oxygen-dependent choline dehydrogenase OS=Staphylococcus xylosus OX=1288 GN=betA PE=3 SV=1
Q4A0Q1	2.51e-257	1	538	8	548	Oxygen-dependent choline dehydrogenase OS=Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) OX=342451 GN=betA PE=3 SV=1
Q2FDP9	4.02e-256	1	538	11	551	Oxygen-dependent choline dehydrogenase OS=Staphylococcus aureus (strain USA300) OX=367830 GN=betA PE=3 SV=1
A5IW37	4.02e-256	1	538	11	551	Oxygen-dependent choline dehydrogenase OS=Staphylococcus aureus (strain JH9) OX=359786 GN=betA PE=3 SV=1
Q2YWJ5	4.02e-256	1	538	11	551	Oxygen-dependent choline dehydrogenase OS=Staphylococcus aureus (strain bovine RF122 / ET3-1) OX=273036 GN=betA PE=3 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.918191	0.080783	0.000405	0.000309	0.000123	0.000226

TMHMM Annotations help

There is no transmembrane helices in MGYG000003791_00372.