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CAZyme Information: MGYG000003797_01406

You are here: Home > Sequence: MGYG000003797_01406

Basic Information | Genomic context | Full Sequence | Enzyme annotations |  CAZy signature domains |  CDD domains | CAZyme hits | PDB hits | Swiss-Prot hits | SignalP and Lipop annotations | TMHMM annotations

Basic Information help

Species
Lineage Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus;
CAZyme ID MGYG000003797_01406
CAZy Family CBM40
CAZyme Description Sialidase B
CAZyme Property
Protein Length CGC Molecular Weight Isoelectric Point
774 85665.66 6.9016
Genome Property
Genome Assembly ID Genome Size Genome Type Country Continent
MGYG000003797 1673820 MAG Canada North America
Gene Location Start: 239;  End: 2563  Strand: -

Full Sequence      Download help

Enzyme Prediction      help

EC 4.2.2.15 3.2.1.18

CAZyme Signature Domains help

Family Start End Evalue family coverage
GH33 314 752 5.8e-75 0.9327485380116959
CBM40 123 302 9e-60 0.9608938547486033

CDD Domains      download full data without filtering help

Cdd ID Domain E-Value qStart qEnd sStart sEnd Domain Description
COG4409 NanH 0.0 1 773 1 728
Neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis].
cd15482 Sialidase_non-viral 5.85e-56 314 760 5 338
Non-viral sialidases. Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.
pfam02973 Sialidase 1.82e-27 122 302 8 185
Sialidase, N-terminal domain.
pfam13088 BNR_2 3.60e-26 537 737 82 275
BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.
COG4692 COG4692 1.84e-04 575 736 195 352
Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis].

CAZyme Hits      help

Hit ID E-Value Query Start Query End Hit Start Hit End
VFH50122.1 0.0 1 774 1 740
CAR69021.1 0.0 1 774 1 740
AVD75144.1 0.0 1 774 1 740
CBW36430.1 0.0 1 774 1 740
VFH36906.1 0.0 1 774 1 740

PDB Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
4YW1_A 0.0 117 774 1 658
ChainA, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW1_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW2_A Chain A, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW2_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW3_A Chain A, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW3_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW4_A Streptococcus pneumoniae sialidase NanC [Streptococcus pneumoniae],4YW4_B Streptococcus pneumoniae sialidase NanC [Streptococcus pneumoniae],4YW5_A Chain A, Neuraminidase C [Streptococcus pneumoniae TIGR4],4YW5_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4],5F9T_A Chain A, Neuraminidase C [Streptococcus pneumoniae TIGR4],5F9T_B Chain B, Neuraminidase C [Streptococcus pneumoniae TIGR4]
4YZ1_A 0.0 118 774 21 677
CrystalStructure of Streptococcus pneumoniae NanC, apo structure. [Streptococcus pneumoniae TIGR4],4YZ1_B Crystal Structure of Streptococcus pneumoniae NanC, apo structure. [Streptococcus pneumoniae TIGR4],4YZ2_A Crystal Structure of Streptococcus pneumoniae NanC, in complex with 2-deoxy-2,3-didehydro-N-acetylneuraminic acid. [Streptococcus pneumoniae],4YZ2_B Crystal Structure of Streptococcus pneumoniae NanC, in complex with 2-deoxy-2,3-didehydro-N-acetylneuraminic acid. [Streptococcus pneumoniae],4YZ3_A Crystal Structure of Streptococcus pneumoniae NanC, in complex with Oseltamivir. [Streptococcus pneumoniae TIGR4],4YZ3_B Crystal Structure of Streptococcus pneumoniae NanC, in complex with Oseltamivir. [Streptococcus pneumoniae TIGR4],4YZ4_A Crystal Structure of Streptococcus pneumoniae NanC, in complex with N-Acetylneuraminic acid. [Streptococcus pneumoniae],4YZ4_B Crystal Structure of Streptococcus pneumoniae NanC, in complex with N-Acetylneuraminic acid. [Streptococcus pneumoniae],4YZ5_A Crystal Structure of Streptococcus pneumoniae NanC, in complex with 3-Sialyllactose [Streptococcus pneumoniae],4YZ5_B Crystal Structure of Streptococcus pneumoniae NanC, in complex with 3-Sialyllactose [Streptococcus pneumoniae]
2JKB_A 1.32e-225 118 773 29 686
Crystalstructure of Streptococcus pneumoniae NanB in complex with 2, 7-anhydro-Neu5Ac [Streptococcus pneumoniae TIGR4]
2VW0_A 1.91e-225 118 773 40 697
Crystalstructure of the NanB sialidase from Streptococcus pneumoniae [Streptococcus pneumoniae],2VW1_A Crystal structure of the NanB sialidase from Streptococcus pneumoniae [Streptococcus pneumoniae],2VW2_A Crystal structure of the NanB sialidase from Streptococcus pneumoniae [Streptococcus pneumoniae],4FOQ_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-aminoethanesulfonic acid [Streptococcus pneumoniae],4FOV_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 3-Cyclohexyl-1-propylsulfonic acid [Streptococcus pneumoniae],4FOW_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 3-ammoniopropane-1-sulfonate [Streptococcus pneumoniae],4FOY_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-(Benzylammonio)ethanesulfonate [Streptococcus pneumoniae],4FP2_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2[(Cyclohexylmethyl)ammonio]sulfonate [Streptococcus pneumoniae],4FP3_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(Furan-2-ylmethyl)ammonio]sulfonate [Streptococcus pneumoniae],4FPC_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Chlorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPE_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Methoxybenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPF_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Chlorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPG_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Hydroxybenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPH_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Fluorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPJ_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Methoxybenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPK_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-methylbenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPL_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3,4-dichlorobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPO_B Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-chloro-4-methoxybenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FPY_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Bromobenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae],4FQ4_A Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Fluoro-3-methylbenzyl)ammonio]ethanesulfonate [Streptococcus pneumoniae]
4XYX_A 6.18e-225 118 773 1 658
NanBplus Optactamide [Streptococcus pneumoniae]

Swiss-Prot Hits      download full data without filtering help

Hit ID E-Value Query Start Query End Hit Start Hit End Description
Q54727 1.05e-224 118 773 40 697
Sialidase B OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) OX=170187 GN=nanB PE=1 SV=2
Q27701 2.12e-182 120 771 86 755
Anhydrosialidase OS=Macrobdella decora OX=6405 PE=1 SV=1
P29767 4.34e-58 117 745 188 809
Sialidase OS=Clostridium septicum OX=1504 PE=3 SV=1
P31206 2.02e-14 323 745 203 526
Sialidase OS=Bacteroides fragilis (strain YCH46) OX=295405 GN=nanH PE=3 SV=2

SignalP and Lipop Annotations help

This protein is predicted as SP

Other SP_Sec_SPI LIPO_Sec_SPII TAT_Tat_SPI TATLIP_Sec_SPII PILIN_Sec_SPIII
0.000317 0.998723 0.000398 0.000194 0.000184 0.000157

TMHMM  Annotations      help

There is no transmembrane helices in MGYG000003797_01406.