galactose mutarotase_like. Galactose mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose. Beta-D-galactose is produced by the degradation of lactose, a disaccharide composed of beta-D-glucose and beta-D-galactose. This epimerization reaction is the first step in the four-step Leloir pathway, which converts galactose into metabolically important glucose. This epimerization step is followed by the phosophorylation of alpha-D-galactose by galactokinase, an enzyme which can only act on the alpha anomer. A glutamate and a histidine residue of the galactose mutarotase have been shown to be critical for catalysis, the glutamate serves as the active site base to initiate the reaction by removing the proton from the C-1 hydroxyl group of the sugar substrate, and the histidine as the active site acid to protonate the C-5 ring oxygen. Galactose mutarotase is a member of the aldose-1-epimerase superfamily.

galactose-1-epimerase; Provisional

galactose mutarotase. Members of this protein family act as galactose mutarotase (D-galactose 1-epimerase) and participate in the Leloir pathway for galactose/glucose interconversion. All members of the seed alignment for this model are found in gene clusters with other enzymes of the Leloir pathway. This enzyme family belongs to the aldose 1-epimerase family, described by pfam01263. However, the enzyme described as aldose 1-epimerase itself (EC 5.1.3.3) is called broadly specific for D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose. The restricted genome context for genes in this family suggests members should act primarily on D-galactose.

aldose 1-epimerase; Provisional

Aldose 1-epimerase.

Crystalstructure of apo human galactose mutarotase [Homo sapiens],1SNZ_B Crystal structure of apo human galactose mutarotase [Homo sapiens],1SO0_A Crystal structure of human galactose mutarotase complexed with galactose [Homo sapiens],1SO0_B Crystal structure of human galactose mutarotase complexed with galactose [Homo sapiens],1SO0_C Crystal structure of human galactose mutarotase complexed with galactose [Homo sapiens],1SO0_D Crystal structure of human galactose mutarotase complexed with galactose [Homo sapiens]

Thecrystal structure of a possible galactose mutarotase from Streptomyces platensis subsp. rosaceus [Streptomyces platensis],4RNL_B The crystal structure of a possible galactose mutarotase from Streptomyces platensis subsp. rosaceus [Streptomyces platensis],4RNL_C The crystal structure of a possible galactose mutarotase from Streptomyces platensis subsp. rosaceus [Streptomyces platensis],4RNL_D The crystal structure of a possible galactose mutarotase from Streptomyces platensis subsp. rosaceus [Streptomyces platensis]

CrystalStructure of the GalM/aldose Epimerase Homologue from C. elegans, Northeast Structural Genomics Target WR66 [Caenorhabditis elegans],1LUR_B Crystal Structure of the GalM/aldose Epimerase Homologue from C. elegans, Northeast Structural Genomics Target WR66 [Caenorhabditis elegans]

ChainA, galactose mutarotase [Lactococcus lactis],1L7J_B Chain B, galactose mutarotase [Lactococcus lactis],1L7K_A Chain A, galactose mutarotase [Lactococcus lactis],1L7K_B Chain B, galactose mutarotase [Lactococcus lactis],1MMU_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MMU_B Chain B, Aldose 1-epimerase [Lactococcus lactis],1MMX_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MMX_B Chain B, Aldose 1-epimerase [Lactococcus lactis],1MMY_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MMY_B Chain B, Aldose 1-epimerase [Lactococcus lactis],1MMZ_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MMZ_B Chain B, Aldose 1-epimerase [Lactococcus lactis],1MN0_A Chain A, Aldose 1-epimerase [Lactococcus lactis],1MN0_B Chain B, Aldose 1-epimerase [Lactococcus lactis]

ChainA, GALACTOSE MUTAROTASE [Lactococcus lactis],1NS0_B Chain B, GALACTOSE MUTAROTASE [Lactococcus lactis],1NS4_A Chain A, GALACTOSE MUTAROTASE [Lactococcus lactis],1NS4_B Chain B, GALACTOSE MUTAROTASE [Lactococcus lactis]

Galactose mutarotase OS=Mus musculus OX=10090 GN=Galm PE=1 SV=1

Galactose mutarotase OS=Rattus norvegicus OX=10116 GN=Galm PE=1 SV=1

Aldose 1-epimerase OS=Acinetobacter calcoaceticus OX=471 GN=mro PE=1 SV=1

Galactose mutarotase OS=Sus scrofa OX=9823 GN=GALM PE=2 SV=1

Galactose mutarotase OS=Homo sapiens OX=9606 GN=GALM PE=1 SV=1