RHS repeat-associated core domain. This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.

Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only].

Domain of unknown function (DUF4329). This domain is functionally uncharacterized. It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with pfam05593 and pfam03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.

DNRLRE domain. The DNRLRE domain, with a length of about 160 amino acids, appears typically in large, repetitive surface proteins of bacteria and archaea, sometimes repeated several times. It occurs, notably, three times in the C-terminal region of the enzyme disaggregatase from the archaeal species Methanosarcina mazei, each time with the motif DNRLRE, for which the domain is named. Archaeal proteins within this family are described particularly well by the currently more narrowly defined Pfam model, PF06848. Note that the catalytic region of disaggregatase, in the N-terminal portion of the protein, is modeled by a different HMM, PF08480.

Ricin-type beta-trefoil lectin domain-like.

YenB/RHS2complex [Yersinia entomophaga]

ChainG, TccC2 [Photorhabdus luminescens]

ChainA, Rhs family protein [Pseudomonas protegens Pf-5],7Q97_B Chain B, Rhs family protein [Pseudomonas protegens Pf-5]

Structureof the RHS-repeat containing BC component of the secreted ABC toxin complex from Yersinia entomophaga [Yersinia entomophaga],4IGL_D Structure of the RHS-repeat containing BC component of the secreted ABC toxin complex from Yersinia entomophaga [Yersinia entomophaga]

tRNA3(Ser)-specific nuclease WapA OS=Bacillus spizizenii (strain DSM 15029 / JCM 12233 / NBRC 101239 / NRRL B-23049 / TU-B-10) OX=1052585 GN=wapA PE=1 SV=1

tRNA nuclease WapA OS=Bacillus subtilis (strain 168) OX=224308 GN=wapA PE=1 SV=2

tRNA(Glu)-specific nuclease WapA OS=Bacillus subtilis subsp. natto (strain BEST195) OX=645657 GN=wapA PE=1 SV=2

Toxin subunit YenC2 OS=Yersinia entomophaga OX=935293 GN=yenC2 PE=1 SV=1

Toxin subunit YenC1 OS=Yersinia entomophaga OX=935293 GN=yenC1 PE=1 SV=1