dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000004080_00527

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Basic Information help

Species

Lineage

Bacteria; Actinobacteriota; Actinomycetia; Actinomycetales; Actinomycetaceae; Arcanobacterium_A;

CAZyme ID

MGYG000004080_00527

CAZy Family

GT51

CAZyme Description

Penicillin-binding protein 1A

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
708	MGYG000004080_3\|CGC1	75619.5	5.209

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004080	1753974	MAG	United Kingdom	Europe

Gene Location

Start: 28844; End: 30970 Strand: -

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000004080_00527.

CAZyme Signature Domains help

Family	Start	End	Evalue	family coverage
GT51	131	302	6.1e-36	0.9717514124293786

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
COG0744	MrcB	1.31e-90	84	698	19	606	Membrane carboxypeptidase (penicillin-binding protein) [Cell wall/membrane/envelope biogenesis].
TIGR02074	PBP_1a_fam	3.23e-85	140	691	2	531	penicillin-binding protein, 1A family. Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
COG5009	MrcA	4.21e-42	92	688	15	718	Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis].
pfam00912	Transgly	7.84e-39	127	303	1	177	Transglycosylase. The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
COG4953	PbpC	1.61e-36	92	699	4	574	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis].

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
VEI13328.1	1.84e-137	86	707	26	641
QRV02169.1	2.92e-126	86	704	32	644
QOR47724.1	1.80e-124	86	707	31	645
QOQ39723.1	1.51e-122	86	707	31	645
QTG75491.1	2.99e-122	86	707	31	645

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
3ZG8_B	2.23e-30	222	694	2	479	CrystalStructure of Penicillin Binding Protein 4 from Listeria monocytogenes in the Ampicillin bound form [Listeria monocytogenes],3ZG9_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Cefuroxime bound form [Listeria monocytogenes],3ZGA_B Crystal Structure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the Carbenicillin bound form [Listeria monocytogenes]
3ZG7_B	2.38e-28	222	648	2	428	CrystalStructure of Penicillin-Binding Protein 4 from Listeria monocytogenes in the apo form [Listeria monocytogenes]
5CXW_A	6.76e-26	331	703	2	370	Structureof the PonA1 protein from Mycobacterium Tuberculosis in complex with penicillin V [Mycobacterium tuberculosis H37Rv]
5CRF_A	1.80e-23	331	703	2	370	Structureof the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis [Mycobacterium tuberculosis H37Rv],5CRF_B Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis [Mycobacterium tuberculosis H37Rv],5CRF_C Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis [Mycobacterium tuberculosis H37Rv],5CRF_D Structure of the penicillin-binding protein PonA1 from Mycobacterium Tuberculosis [Mycobacterium tuberculosis H37Rv]
4OON_A	1.50e-21	109	378	9	276	Crystalstructure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) [Pseudomonas aeruginosa PAO1]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
A0R7G2	3.07e-54	82	703	74	698	Penicillin-binding protein 1A OS=Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) OX=246196 GN=ponA1 PE=3 SV=1
P71707	9.38e-53	103	703	155	760	Penicillin-binding protein 1A OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=ponA1 PE=1 SV=3
P70997	2.77e-38	97	648	25	577	Penicillin-binding protein 2D OS=Bacillus subtilis (strain 168) OX=224308 GN=pbpG PE=2 SV=3
A0A0H2ZMF9	1.65e-31	131	647	102	618	Penicillin-binding protein 2a OS=Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) OX=373153 GN=pbp2a PE=1 SV=1
Q8DNB6	1.65e-31	131	647	102	618	Penicillin-binding protein 2a OS=Streptococcus pneumoniae (strain ATCC BAA-255 / R6) OX=171101 GN=pbp2a PE=1 SV=1

SignalP and Lipop Annotations help

This protein is predicted as OTHER

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
1.000041	0.000001	0.000000	0.000000	0.000000	0.000000

TMHMM Annotations download full data without filtering help

start	end
84	106