dbCAN-seq: a database of CAZyme sequence and annotation

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CAZyme Information: MGYG000004748_00933

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Basic Information help

Species

Lineage

Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides;

CAZyme ID

MGYG000004748_00933

CAZy Family

GH33

CAZyme Description

Arylsulfatase

CAZyme Property

Protein Length	CGC	Molecular Weight	Isoelectric Point
472		52117.89	6.1868

Genome Property

Genome Assembly ID	Genome Size	Genome Type	Country	Continent
MGYG000004748	4696076	MAG	China	Asia

Gene Location

Start: 255688; End: 257106 Strand: +

Full Sequence Download help

Enzyme Prediction help

No EC number prediction in MGYG000004748_00933.

CDD Domains download full data without filtering help

Cdd ID	Domain	E-Value	qStart	qEnd	sStart	sEnd	Domain Description
cd16026	GALNS_like	0.0	37	438	1	399	galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS). Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
cd16144	ARS_like	7.42e-125	38	455	1	421	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16143	ARS_like	3.71e-121	38	438	1	395	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16146	ARS_like	6.78e-121	38	460	1	409	uncharacterized arylsulfatase. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
cd16145	ARS_like	7.37e-117	38	442	1	415	uncharacterized arylsulfatase subfamily. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.

CAZyme Hits help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End
VTR91273.1	5.46e-134	38	463	24	457
VTS00049.1	1.81e-130	38	469	24	467
AWM40795.1	1.81e-130	38	469	24	467
QEG25923.1	1.81e-130	38	469	24	467
QDT08292.1	2.54e-108	34	467	732	1162

PDB Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
1E33_P	8.44e-77	36	456	1	442	Crystalstructure of an Arylsulfatase A mutant P426L [Homo sapiens]
1E1Z_P	1.67e-76	36	456	1	442	Crystalstructure of an Arylsulfatase A mutant C69S [Homo sapiens]
1E3C_P	1.67e-76	36	456	1	442	Crystalstructure of an Arylsulfatase A mutant C69S soaked in synthetic substrate [Homo sapiens]
1E2S_P	4.62e-76	36	456	1	442	Crystalstructure of an Arylsulfatase A mutant C69A [Homo sapiens]
1AUK_A	9.12e-76	36	456	1	442	HumanArylsulfatase A [Homo sapiens],1N2K_A Crystal structure of a covalent intermediate of endogenous human arylsulfatase A [Homo sapiens],1N2L_A Crystal structure of a covalent intermediate of endogenous human arylsulfatase A [Homo sapiens]

Swiss-Prot Hits download full data without filtering help

Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
Q08DD1	1.14e-78	38	456	21	460	Arylsulfatase A OS=Bos taurus OX=9913 GN=ARSA PE=2 SV=1
P15289	7.87e-75	36	456	19	460	Arylsulfatase A OS=Homo sapiens OX=9606 GN=ARSA PE=1 SV=3
P50428	6.31e-73	38	391	20	394	Arylsulfatase A OS=Mus musculus OX=10090 GN=Arsa PE=1 SV=2
Q32KH5	2.92e-70	6	391	13	399	N-acetylgalactosamine-6-sulfatase OS=Canis lupus familiaris OX=9615 GN=GALNS PE=2 SV=1
Q571E4	2.11e-69	38	433	28	448	N-acetylgalactosamine-6-sulfatase OS=Mus musculus OX=10090 GN=Galns PE=1 SV=2

SignalP and Lipop Annotations help

This protein is predicted as LIPO

Other	SP_Sec_SPI	LIPO_Sec_SPII	TAT_Tat_SPI	TATLIP_Sec_SPII	PILIN_Sec_SPIII
0.000007	0.003623	0.996422	0.000001	0.000002	0.000002

TMHMM Annotations help

There is no transmembrane helices in MGYG000004748_00933.